What are the side effects of alpha-lipoic acid for neuropathy?
Side effects are generally rare and may include insomnia, fatigue, diarrhea, and skin rash. Alpha-lipoic acid can lower blood sugar levels, so people with diabetes or low blood sugar should take alpha-lipoic acid only under the supervision of their health care provider.
Vitamins B-1, B-6, and B-12 have been found to be especially beneficial for treating neuropathy. Vitamin B-1, also known as thiamine, helps to reduce pain and inflammation and vitamin B-6 preserves the covering on nerve endings.
Alpha-lipoic acid (a-lipoic acid or ALA) is a powerful antioxidant cofactor synthesized in mitochondria that could help stimulate nerves and regenerate nerve fibers, thus preventing disease progression.
Neurotropic B vitamins play crucial roles as coenzymes and beyond in the nervous system. Particularly vitamin B1 (thiamine), B6 (pyridoxine), and B12 (cobalamin) contribute essentially to the maintenance of a healthy nervous system.
Diabetic patients with neuropathy treated with alpha-lipoic acid 600 mg i.v. daily for three weeks, have reduced pain, paresthesias, and numbness [14, 80, 81]. According to a recent meta-analysis comprising 1,258 patients, the same treatment ameliorated neuropathic symptoms and deficits after three weeks [81].
What should I avoid while taking alpha-lipoic acid? Avoid using alpha-lipoic acid together with other herbal/health supplements that can also lower your blood sugar. This includes devil's claw, fenugreek, garlic, guar gum, horse chestnut, Panax ginseng, psyllium, and Siberian ginseng.
Eat at least one fruit daily to help heal damaged nerves. Berries, peaches, cherries, red grapes, oranges and watermelon, among others, are loaded with antioxidants, which help to decrease inflammation and reduce nerve damage.
Omega-3–rich foods.
Fish oil has been found to restore the condition of damaged nerves due to the omega-3 found in it. Omega-3 foods such as salmon, tuna, cod, herring, sardines, mackerel, flaxseeds, and chia seeds help improve blood sugar regulation and control inflammation.
Regular exercise, such as walking three times a week, can reduce neuropathy pain, improve muscle strength and help control blood sugar levels. Gentle routines such as yoga and tai chi might also help.
Alpha-lipoic acid supplements are generally considered safe when taken as recommended. However, if you take this supplement when you have a significant thiamin (vitamin B-1) deficiency, alpha-lipoic toxicity might occur. Don't use alpha-lipoic acid if you're a heavy alcohol user.
Can alpha-lipoic acid reverse nerve damage?
ALA's safety and effectiveness can vary among people with diabetes. As with any dietary supplement, you should talk to your doctor before you start taking it. Stop taking ALA immediately if you notice any unusual side effects or if your symptoms worsen. You can't reverse nerve damage.
Electrical Stimulation (ES) accelerates target reinnervation
Electrical stimulation at a frequency of 20Hz for one hour accelerates the outgrowth of axons across the site of surgical repair of transected nerve stumps to result in accelerated target reinnervation.

Orange juice is rich in vitamin C, with 1 cup (240 mL) providing 93% of the Daily Value (DV). Interestingly, this vitamin may offer neuroprotective benefits ( 10 ).
- Step 1: Exercise on a daily basis. ...
- Step 2: Get plenty of sleep. ...
- Step 3: Expose your body to sunlight. ...
- Step 4: Add meditation in your daily routine. ...
- Step 5: Walk barefoot. ...
- Step 6: Drink green tea. ...
- Step 7: Food you eat matters.
Herbs that are in the “nervine” category can be very nourishing and soothing to the nerve tissue. Among the best are Chinese skullcap, lemon balm, wood betony, St. John's wort, chamomile, prickly ash and milky oats.
There is no cure for peripheral neuropathy but proper treatment will slow progression and address your symptoms. If the cause of the foot neuropathy is known, then treatment of the underlying cause may provide relief.
Studies show that roughly 30-40% of supplemental ALA is absorbed. As such, absorption might be enhanced when taken on an empty stomach [3]. The best time to take alpha-lipoic acid is typically first thing in the morning, at least 30 minutes before eating or drinking.
But alpha lipoic acid plays another critical role—protecting your cells from oxidative damage, including those in your kidneys.
There is not enough research and evidence on the extra benefits and potential side effects of taking higher doses, so medical professionals do not recommend it. There is not enough evidence on its safety for use in children, however, so adults should always keep ALA in a safe place.
Conclusions: Dietary alpha-lipoic acid supplementation in SHRs lowered the systolic blood pressure, cytosolic [Ca2+]i, blood glucose and insulin levels, and tissue aldehyde conjugates, and attenuated adverse renal vascular changes.
Is alpha-lipoic acid good for nerve pain?
Possibly Effective for
Nerve pain in people with diabetes (diabetic neuropathy). Taking 600-1800 mg of alpha-lipoic acid by mouth or by IV seems to improve symptoms such as burning, pain, and numbness in the legs and arms of people with diabetes. Lower doses of alpha-lipoic acid don't seem to work.
Nerves: Bananas are high in B vitamins, which help calm the nervous system. PMS: The vitamin B6 that bananas contain regulates blood glucose levels, which can affect your mood. Strokes: According to research, eating bananas as part of a regular diet can cut the risk of death by strokes by as much as 40%!
Many of the conditions that cause leg and foot numbness, such as nerve pressure, improve with rest. Ice. Ice can help reduce swelling that can put pressure on nerves. Apply cold compresses or wrapped icepacks to numb legs and feet for 15 minutes at a time several times daily.
In conclusion, six-week honey treatment helped in reducing dyslipidemia and oxidative stress. Honey given along with insulin for six-weeks improved sensory nerve conduction velocity in experimental diabetic neuropathy Wistar rats.
Exercise also promotes blood flow to the nerves in the legs and feet. Researchers believe that regular exercise may create a long-lasting expansion in blood vessels in the feet, nourishing damaged nerves back to health. Start with a daily walk, gradually increasing pace and distance.
Regeneration time depends on how seriously your nerve was injured and the type of injury that you sustained. If your nerve is bruised or traumatized but is not cut, it should recover over 6-12 weeks. A nerve that is cut will grow at 1mm per day, after about a 4 week period of 'rest' following your injury.
Nutritional or vitamin imbalances, alcoholism, and exposure to toxins can damage nerves and cause neuropathy. Vitamin B12 deficiency and excess vitamin B6 are the best-known vitamin-related causes. Several medications have been shown to occasionally cause neuropathy.
Vicks Vapor Rub® – Massaging one's feet with Vicks, particularly at night, soothes neuropathic pain and distress in one's feet and legs. It is also excellent for softening your toe nails and diminishing common toe nail problems. Warm/Cool Baths and Showers - Excellent de-stressors and can help with reducing pain.
Walking can reduce the pain and other symptoms of neuropathy from the nerve damage in your feet and lower legs. Walking and other light aerobic exercises have various benefits for people affected by neuropathy, which is a wide range of conditions involving disease and damage to the peripheral nerves.
- amitriptyline – also used for treatment of headaches and depression.
- duloxetine – also used for treatment of bladder problems and depression.
- pregabalin and gabapentin – also used to treat epilepsy, headaches or anxiety.
Can too much alpha-lipoic acid be harmful?
Abstract. Introduction: Alpha lipoic acid (ALA) is a potent antioxidant used to treat a variety of disorders. Although ALA is considered a very safe supplement and intoxication is very rare, acute high-dose ingestions can cause mortality.
Numerous clinical studies have found that magnesium has beneficial effects in patients suffering from neuropathic pain, dysmenorrhea, tension headache, acute migraine attack, and others.
Alpha-lipoic acid and longevity
Animal studies show that alpha-lipoic acid prolonged lifespan in certain species [24] but reduced it in progeric mice [25]. There is currently no data supporting such an effects on human lifespan, and studies of the long-term effects on health have not been conducted.
Nerves recover slowly, and maximal recovery may take many months or several years. You'll need regular checkups to make sure your recovery stays on track. If your injury is caused by a medical condition, your doctor will treat the underlying condition.
A new study published in Current Biology identifies the biological triggers that promote quicker nerve regeneration. From their previous studies, the researchers knew that damaged nerves regrow more quickly when "stress granules" in the site of the nerve injury are broken apart.
- Numbness or tingling in the hands and feet.
- Feeling like you're wearing a tight glove or sock.
- Muscle weakness, especially in your arms or legs.
- Regularly dropping objects that you're holding.
- Sharp pains in your hands, arms, legs, or feet.
- A buzzing sensation that feels like a mild electrical shock.
ALA did slow the progression of neuropathy, however, with 29% of patients in the treatment group experiencing worsening symptoms compared with 38% of those on placebo.
Introduction: Alpha lipoic acid (ALA) is a potent antioxidant used to treat a variety of disorders. Although ALA is considered a very safe supplement and intoxication is very rare, acute high-dose ingestions can cause mortality.
Several studies have found that they can improve insulin resistance. Studies also found that alpha-lipoic acid supplements can help with neuropathy -- nerve damage -- caused by diabetes or cancer treatment.
Dosing. Alpha-lipoic acid has most often been used by adults in doses of 600-1800 mg by mouth daily for up to 6 months. Speak with a healthcare provider to find out what dose might be best for a specific condition.
What is the best vitamin for foot neuropathy?
Vitamin B-12 is present in some foods and helps with proper nerve function and red blood cell production. People who don't get enough vitamin B-12 may have a higher risk of neuropathy and other nervous system (neurological) problems.
But alpha lipoic acid plays another critical role—protecting your cells from oxidative damage, including those in your kidneys.
Higher doses are not recommended, as there's no evidence that they provide extra benefits. Furthermore, animal research has found that extremely high doses of alpha-lipoic acid may promote oxidation, alter liver enzymes, and place strain on liver and breast tissue (38, 39 ).
While you can't reverse the damage from neuropathy, there are ways to help manage the condition, including: lowering your blood sugar. treating nerve pain. regularly checking your feet to make sure they are free of injury, wounds, or infection.
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